ASSOCIATION ASSOCIATION OF SHINE AND LAL INDEX β-THALASSEMIA TRAIT SCREENING RESULTS WITH ANAEMIA AND LOW BIRTH WEIGH
Abstract
Beta thalassemia trait are more likely to have anemia which leading to intrauterine hypoxia and adverse uterine conditions. Adverse intrauterine environment has been shown to have a significant impact on the risk of low birth weight. Therefore, this study aims to investigate association between Shine and Lal index β-thalassemia trait screening results with anaemia and lowbirth weight. A retrospective study design was conducted based on medical records of mothers and their infants born in 2022 at a regional hospital, in East Nusa Tenggara. The inclusion criteria were being live birth, singleton births and gestational age >28 weeks. Mothers didn’t have complete records were excluded from study. Analysis uses chi-square test to evaluate the relationship between dependent and independent variables, This study identified 738 eligible samples. The incidence of suspected β-thalassemia trait according Shine and Lal Index was about 42.5%. There is a significant relationship between Shine and Lal β-thalassemia trait screening results with maternal anaemia and no relationship between Shine and Lal index β-thalassemia trait screening results and LBW
Downloads
References
Barrett, A.N., Saminathan, R., and Choolani, M. (2017) ‘Thalassaemia Screening and Confirmation of Carriers in Parents’. Best Practice & Research Clinical Obstetrics & Gynaecology [online] 39, 27–40. available from
Bharti, O.K., Sood, R.K., Sharma, H.R., Kaur, H., Minhas, V., Chauhan, R., Nigam, N., and Phull, A. (2020) ‘Mean Corpuscular Volume/Mean Corpuscular Hemoglobin Values Are Not Reliable Predictors of the β-Thalassemia Carrier Status among Healthy Diverse Populations of Himachal Pradesh, India’. Asian Journal of Transfusion Science [online] 14 (2), 172. available from
Blencowe, H., Krasevec, J., Onis, M. de, Black, R.E., An, X., Stevens, G.A., Borghi, E., Hayashi, C., Estevez, D., Cegolon, L., Shiekh, S., Hardy, V.P., Lawn, J.E., and Cousens, S. (2019) ‘National, Regional, and Worldwide Estimates of Low Birthweight in 2015, with Trends from 2000: A Systematic Analysis’. Lancet Glob Health 7
Breymann, C. (2015) ‘Iron Deficiency Anemia in Pregnancy’. Seminars in Hematology [online] 52 (4), 339–347. available from
Charoenboon, C., Jatavan, P., Traisrisilp, K., and Tongsong, T. (2016) ‘Pregnancy Outcomes among Women with Beta-Thalassemia Trait’. Archives of Gynecology and Obstetrics [online] 293 (4), 771–774. available from
Cunningham, F.G., Leveno, K.J., Bloom, S.L., Dashe, J.S., Hoffman, B.L., Casey, B.M., and Spong, C.Y. (2018) in William Obstetric, Twenty-Fifth Edition. Twenty-Fifth. ed. by Moyer, A. and Brown, R.Y. 11 44. New York: McGraw-Hill Education, 847–852
El-Shanshory, M.R., Sherief, L.M., Hassab, H.M., Ragab, S.M., Yahia, S., Mansour, A.K., Ahmed, A.S., Abdou, S.H., Helmy, A.M., Watany, M.M., Gad ALllah, A.M., Guindy, M.A., Mourad, Z.I., Soliman, M.A., El-Farahaty, R.M., El-Dahtory, F., Darwish, A., Elmabood, S.A., Kabbash, I.A., and Saied, S.M. (2021) ‘Prevalence of Iron Deficiency Anemia and Beta Thalassemia Carriers among Relatives of Beta Thalassemia Patients in Nile Delta Region, Egypt: A Multicenter Study’. Journal of the Egyptian Public Health Association [online] 96 (1), 27. available from
Hanprasertpong, T., Kor-anantakul, O., Leetanaporn, R., Suntharasaj, T., Suwanrath, C., Pruksanusak, N., and Pranpanus, S. (2013) ‘Pregnancy Outcomes amongst Thalassemia Traits’. Archives of Gynecology and Obstetrics [online] 288 (5), 1051–1054. available from
Hernaningsih, Y., Syafitri, Y., Indrasari, Y.N., Rahmawan, P.A., Andarsini, M.R., Lesmana, I., Moses, E.J., Abdul Rahim, N.A., and Yusoff, N.M. (2022) ‘Analysis of Common Beta-Thalassemia (β-Thalassemia) Mutations in East Java, Indonesia’. Frontiers in Pediatrics 10, 1–7
Huang, X.C., Qiu, X.Q., Zeng, X.Y., Liu, S., Wei, F.L., Li, Y.N., Liu, T., Wu, Y.N., Feng, B.Y., Jiang, Q.J., and Huang, D.P. (2019) ‘[Associations of parental thalassemia with preterm birth and low birth weight]’. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi 40 (5), 596–600
Copyright (c) 2023 Susanti susanti, Muhammad Miftahussurur, Dominicus Husada, Woro Setia Ningtyas
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with IJNMS agree to the following terms
- Authors retain copyright licensed under a Creative Commons Attribution-ShareAlike 4.0 International License that allows others to share the work non-commercially with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). Authors can archive pre-print and post-print or publisher's version/PDF.
_IJNMS.png)
