Mini Review Biomarkers as Early Detection Tool for Silica Dust Exposure-induced Health Problems

  • Kusmiyati Kusmiyati Politeknik Kesehatan Kemenkes Kupang
Keywords: Antioxidant; biomarker; detection; inflammatory; reactive oxygen species; silica


The silica dust is widely distributed on earth’s surface resulting from various activities. This mineral may result in lung damage initially presenting changes of many compounds in biological systems. Silica exposure on lung tissues triggers reactive oxygen species (ROS) production, influences endogenous antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase), and release of inflammatory mediators (IL-1, IL-6, TNF-α). These biomarkers are developed as marker of silica exposure effect in the body. It is concluded that development of biomarkers is warranted for early detection of silica exposure-induced health problems in order to prevent its progression into serious diseases.


Download data is not yet available.


Abdelaziz, R.R., Elkashef, W.F. & Said, E., 2016. Tadalafil Reduces Airway Hyperactivity and Protects Against Lung and Respiratory Airways Dysfunction in a Rat Model of Silicosis. International Immunopharmacology, 40, pp.530–541.
Andre, B. et al., 2013. Serum selenium and selenoprotein P in patients with silicosis. Journal of Trace Elements in Medicine and Biology, 27, pp.40–44.
Appelqvist, A.J.H., 2010. Regulation of apoptosis-associated lysosomal membrane Permeabilization Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis, 15(May 2014), pp.527–540.
Bernardo, E. et al., 2016. Cell-Based Therapy for Silicosis Cell-Based Therapy for Silicosis. Stem Cells International, 2016(March), p.9.
Booth, K.A. & Stoia, 2013. Anatomy, Physiology and Disease for The Health Professions, Cina: Mc Graw-Hill Companies.
Castranova, V., 2004. Signaling Pathways Controlling. Free Radical Biology and Medicine, 37(7), pp.916–925.
Cheresh, P. et al., 2013. Oxidative Stress and Pulmonary Fibrosis. Biochim Biophys Acta, 1832(7), pp.1028–1040.
Freire, J. et al., 2013. Silica-induced Chronic Inflammation Promotes Lung Carcinogenesis in the Context of an Immunosuppressive. Neoplasia, 15(8), p.913–924, IN15–IN18. Available at:
IAPA, 2008. Silica in The Workplace, Industrial Acciden Prevention Association.
Liu, H. et al., 2009. Health risk assessment by measuring plasma malondialdehyde ( MDA ), urinary 8-hydroxydeoxyguanosine ( 8-OH-dG ) and DNA strand breakage following metal exposure in foundry workers. Journal of Hazardous Matterials, 170, pp.699–704.
Oeckinghaus, A. & Ghosh, S., 2009. The NF- k B Family of Transcription Factors and Its Regulation. Cold Spring Harb Perspect Biol, 1, pp.1–15.
Øvrevik, J. et al., 2015. Activation of Proinflammatory Responses in Cells of the Airway Mucosa by Particulate Matter: Oxidant- and Non-Oxidant-Mediated Triggering Mechanisms. Biomolecules, 5, pp.1399–1440.
Palabiyik, S.S. et al., 2013. Immunomodulation and Oxidative Stress Caused by Silicosis. Arh Hig Rada Toksikol, 64, pp.431–437.
Pandey, J.K. & Agarwal, D., 2012. Biomarker: A Potensial Prognostic Tool for Silicosis. Indian Journal and Environmental Medicine, 16(3), pp.101–107.
Richter, K. et al., 2015. Redox- fi brosis : Impact of TGF β 1 on ROS generators , mediators and functional consequences. Redox Biology, 6, pp.344–352.
Sato, T. et al., 2015. Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation. J Immunol, 180, pp.7648–7654.
Sharan, S. et al., 2010. Pulmonary Fibrosis IL-6 receptor-mediated lung Th2 cytokine networking in silica-induced pulmonary Fibrosis. Arch Toxicol, 84(December), pp.947–955.
Tiwari, 2005. Biomarkers of Silicosis: Potential Candidates. Indian Journal of Occupational and Environmental Medicine, 9(3), pp.103–106.
Wallace, R., 2008. Public Health and Preventive Medicine fifteenth., USA: Mc Graw Hill Companies, Inc.
How to Cite
Kusmiyati, K. (2019). Mini Review Biomarkers as Early Detection Tool for Silica Dust Exposure-induced Health Problems. INTERNATIONAL JOURNAL OF NURSING AND MIDWIFERY SCIENCE (IJNMS), 3(3), 159-164.